When Chris started a phase-three clinical trial for a promising ALS drug, the Snows were hopeful. As the months wore on and Chris' disease didn't seem to be progressing at all, they were thrilled. Each month with no change to Chris' health made the notion that this experimental medicine could stop his ALS in its tracks seem like a real possibility. And then, in April 2020, nine months after Chris joined the trial, that possibility crumbled with one photograph. Looking at that picture, Kelsie realized Chris' smile had changed slightly and that their story and the trajectory of Chris' illness had changed completely. In this episode, Chris and Kelsie talk about how devastating the loss of his smile and all of the losses that came after it have been and how, even amidst the most painful developments since his ALS diagnosis, they still cling to hope.